A: It promotes homologous recombination using a donor DNA template

Wed, 06 May 2026 04:53:56 +0000

Understanding How A Promotes Homologous Recombination Using a Donor DNA Template Homologous recombination is a critical biological process that enables precise DNA repair, genetic variation, and stable integration of donor DNA sequences into host genomes. Understanding the mechanisms that drive homologous recombination is essential in molecular biology, genetic engineering, and therapeutic gene editing. One compelling system that leverages homologous recombination using a donor DNA template is widely studied, especially in gene therapy and genome modification applications. This article explores how such systems promote homologous recombination through a carefully designed donor DNA template. ### What Is Homologous Recombination? Homologous recombination (HR) is a natural DNA repair pathway that aligns homologous or identical DNA sequences to exchange genetic information accurately. It plays a vital role in maintaining genomic integrity, especially during double-strand break (DSB) repair. Utilizing a donor DNA template allows the cell to insert a desired genetic sequence at a specific locus, enabling precise genome editing.